608 The historical efficacy of Centella asiatica on stretchmarks demonstrated

Commonly associated with pregnancy, stretchmarks appear whenever the body experience a rapid growth. Into dermis, collagen fibres are altered loss of orientation and elastic network is disrupted leading to fibrotic organisation. This results epidermal tearing which produce skin lesions. Centella asiatica one most well-known medicinal plants rich in triterpenic actives molecules traditionally used treat wounds help repair. The aim this study was evaluate extract as natural way solve concern. A complete biological evaluation has started vitro tests on fibroblasts. We have evaluated their proliferation based scratch assay model genes expression by RT-qPCR. At ex vivo level, stretch marked explants, elastin were quantified immunofluorescence. Collagen fibre’s occupation dermis analysed after Sirius red staining specific software analysis. Finally, clinical 54 women carried out during 28 days. Thus, we proven that at 10μg/mL stimulated fibroblasts proliferation. Regarding genetic expression, significantly reduced extracellular matrix degradation (-149% MMP1 -50% MMP7) fibrosis (-128% CTGF -58% PTK2). On explant, 0.5% increased 49% production 37%. thickness 39% centre stretchmark, elasticity vascularisation improved 62% 162% respectively. self-assessed appearance ameliorated 42%. Based mechanisms behind formation stretchmarks, restores optimising organisation for visible remodelling effect.